Mechanism, dynamics, and biological existence of multistability in a large class of bursting neurons

Multistability, the coexistence of multiple attractors in a dynamical system, is explored in bursting nerve cells. A modeling study is performed to show that a large class of bursting systems, as defined by a shared topology when represented as dynamical systems, is inherently suited to support multistability. We derive the bifurcation structure and parametric trends leading to multistability in these systems. Evidence for the existence of multirhythmic behavior in neurons of the aquatic mollusc Aplysia californica that is consistent with our proposed mechanism is presented. Although these experimental results are preliminary, they indicate that single neurons may be capable of dynamically storing information for longer time scales than typically attributed to nonsynaptic mechanisms.Comment: 24 pages, 8 figure

Rotationally induced Penning ionization of ultracold photoassociated helium dimers

We have studied photoassociation of metastable \tripS helium atoms near the \tripS-\tripP asymptote by both ion detection in a magneto-optical trap and trap-loss measurements in a magnetic trap. A detailed comparison between the results of the two experiments gives insight into the mechanism of the Penning ionization process. We have identified four series of resonances corresponding to vibrational molecular levels belonging to different rotational states in two potentials. The corresponding spin states become quasi-purely quintet at small interatomic distance, and Penning ionization is inhibited by spin conservation rules. Only a weak rotational coupling is responsible for the contamination by singlet spin states leading to a detectable ion signal. However, for one of these series Bose statistics does not enable the rotational coupling and the series detected through trap-loss does not give rise to sufficient ionization for detection.Comment: 7 pages, 4 figures, submitted to EuroPhysics Letter

Genetic determinants of co-accessible chromatin regions in activated T cells across humans.

Over 90% of genetic variants associated with complex human traits map to non-coding regions, but little is understood about how they modulate gene regulation in health and disease. One possible mechanism is that genetic variants affect the activity of one or more cis-regulatory elements leading to gene expression variation in specific cell types. To identify such cases, we analyzed ATAC-seq and RNA-seq profiles from stimulated primary CD4+ T cells in up to 105 healthy donors. We found that regions of accessible chromatin (ATAC-peaks) are co-accessible at kilobase and megabase resolution, consistent with the three-dimensional chromatin organization measured by in situ Hi-C in T cells. Fifteen percent of genetic variants located within ATAC-peaks affected the accessibility of the corresponding peak (local-ATAC-QTLs). Local-ATAC-QTLs have the largest effects on co-accessible peaks, are associated with gene expression and are enriched for autoimmune disease variants. Our results provide insights into how natural genetic variants modulate cis-regulatory elements, in isolation or in concert, to influence gene expression

Medical Evidence of Human Rights Violations against Non-Arabic-Speaking Civilians in Darfur: A Cross-Sectional Study

Alexander Tsai and colleagues review medical records from the Amel Centre, Sudan, to assess consistency between recorded medical evidence and patient reports of human rights violations by the Government of Sudan and Janjaweed forces

MAGNETIC PROPERTIES OF NICKEL-COPPER AND NICKEL-COBALT ALLOYS

This paper reports on the effects of alloy composition and applied stress on the magnetic properties of nickel, nickel-copper and nickel-cobalt alloys. The reduction in saturation magnetization on addition of copper to nickel was greater than expected on the basis of a simple rigid band approximation, however the effects of adding cobalt to nickel were very close to expectations. The saturation magnetostriction λs of the copper-nickel alloys was reduced by the addition of copper, however the rate of change of magnetostriction with magnetization, dλ/dM was increased on addition of copper. The change in anhysteretic and maximum differential susceptibility with stress was found to be consistent with recent theoretical models only at stress amplitudes below 25 MPa

Research Article. A new gravity laboratory in Ny-Ålesund, Svalbard

The Norwegian Mapping Authority (NMA) has recently established a new gravity laboratory in Ny-Ålesund at Svalbard, Norway. The laboratory consists of three independent pillars and is part of the geodetic core station that is presently under construction at Brandal, approximately 1.5 km north of NMA’s old station. In anticipation of future use of the new gravity laboratory, we present benchmark gravity values, gravity gradients, and final coordinates of all new pillars. Test measurements indicate a higher noise level at Brandal compared to the old station. The increased noise level is attributed to higher sensitivity to wind.We have also investigated possible consequences of moving to Brandal when it comes to the gravitational signal of present-day ice mass changes and ocean tide loading. Plausible models representing ice mass changes at the Svalbard archipelago indicate that the gravitational signal at Brandal may differ from that at the old site with a size detectable with modern gravimeters. Users of gravity data from Ny-Ålesund should, therefore, be cautious if future observations from the new observatory are used to extend the existing gravity record. Due to its lower elevation, Brandal is significantly less sensitive to gravitational ocean tide loading. In the future, Brandal will be the prime site for gravimetry in Ny-Ålesund. This ensures gravity measurements collocated with space geodetic techniques like VLBI, SLR, and GNSS